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. 2021 Dec 2;11:23325. doi: 10.1038/s41598-021-02313-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Illustrative figure depicting the appearance of CBF maps with low versus high sCoV in sagittal (left) coronal (middle) and axial (right) orientations. Top row, average non-PVC CBF maps for 10 participants with the lowest sCoV in GM ROI from the total cohort studied. This averaged CBF map representing low sCoV appears as expected, with high grey-white matter contrast, and increased perfusion in the region of the posterior cingulate cortex (PCC) and precuneus (see filled arrow). Bottom row, average non-PVC CBF maps for 10 participants with the highest sCoV in GM. The averaged CBF map for highest sCoV shows lower cortical perfusion overall, most notably in the posterior vascular territory (see open arrow), suggesting too short post labelling delay (PLD)/prolonged ATT.