Table 1.
Neuropsychological and demographic summary of participants.
| Controls n = 20 | subjective cognitive decline (SCD) n = 44 | Mild cognitive impairment (MCI) n = 45 | Probable AD (AD) n = 13 | Group statistic | |
|---|---|---|---|---|---|
| ACE-III (SD) | 94.6(3.8) | 91.7(4.9) | 85.2(7.1) | 79.2(6.2) | F(3,118) = 27.4 p < 0.0001 |
| Age (SD) | 67.4(8.3) | 69.0(7.7) | 71.1(7.1) | 74.9(6.2) | F(3,118) = 3.3 p = 0.024 |
|
Sex (% Female) |
80 | 59 | 51 | 23 | χ2 = 10.9, p = 0.012 |
| Vascular risk factor ≥ 2 (%) | 30 | 36 | 31 | 46 | χ2 = 1.3, p = 0.739 |
Addenbrooke’s Cognitive Examination-III (ACE-III) and age are tabulated as group mean (standard deviation). ANOVA result comparing ACE-III and age, and a χ2 test comparing frequency distributions of sex and aggregated vascular risk factor across groups, is reported in the last column. Vascular risk factor is an aggregated measure for hypertension, dyslipidaemia, diabetes, and smoking, with a score of 1 for presence or treatment of each factor (range 0 to 4). Post-hoc pair-wise tests revelated a significant difference in age between controls and AD (p = 0.03). Comparing ACE-III between groups in post-hoc tests, significant differences were found for all pair-wise comparisons (p < 0.01), except for between control and SCD groups (p = 0.38).