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. 2021 Nov 29;53(11):1683–1688. doi: 10.1038/s12276-021-00711-x

Fig. 3. Dual functions of histone sumoylation in transcription.

Fig. 3

a In the promoter region, the elimination of ubiquitin and SUMO from histones by Ubp8 and Ulp2, respectively, recruits Ctk1 to chromatin to facilitate the transition between transcriptional initiation and elongation. b In the 5′ ORF region, H3K4me2 and histone (poly)sumoylation individually provide binding platforms for Set3 and Cpr1 in the Set3 complex, including two HDAC enzymes, Hst1 and Hos2, to suppress internal cryptic initiation.