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. 2021 Dec 2;11:23280. doi: 10.1038/s41598-021-02695-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Screening heterogenous cell lines leads to only few potential targets. (A) Heatmap showing the alterations of representation of 27,500 shRNAs in HL-60, Kasumi-1 and MV4-11 exposed to sublethal concentrations of azacytidine (AZA) at day 5. (B) Heatmap showing the alterations of representation of 27,500 shRNAs in HL-60, Kasumi-1, MV4-11 and primary human blasts exposed to sublethal concentrations of cytarabine (AraC) at day 5. (C) Heatmap depicting changes in representation of 27,500 shRNAs over the course of 5 days in HL-60, Kasumi-1 and MV4-11.