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. Author manuscript; available in PMC: 2022 Dec 3.
Published in final edited form as: Circ Res. 2021 Oct 27;129(12):e215–e233. doi: 10.1161/CIRCRESAHA.121.319066

Figure 8. In vivo knock-down of DNMT3A in femoral artery reduces wire injury-induced neointima formation.

Figure 8.

Femoral arteries were coated with either scramble shRNA (shScr) or DNMT3A shRNA (shDNMT3A) lentivirus coexpressing mCherry immediately following wire injury. Representative immunostainings of 2-week post-injury samples for ACTA2, DNMT3A and DNMT3B are shown (n=4). Green, mCherry (red) and DAPI (blue) were merged. mCherry was used to verify lentiviral infection. Dotted line in image marks the elastic lamina. White line indicates endothelial layer. L, lumen. Scale bars: x20, 100 μm; or x60, 20 μm.