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. Author manuscript; available in PMC: 2022 Jun 1.
Published in final edited form as: Nature. 2021 Nov 24;600(7887):148–152. doi: 10.1038/s41586-021-04141-7

Fig. 4 |. Antibodies to the C-terminal loop or PXL prevent ALK activation.

Fig. 4 |

a, Percent exchange plots for residues 790–798 of the PXL as a function of exposure time. b, Percent exchange plots for the residues 966–972 of the C-term loop as a function of exposure time. c, Binding of GRD or a GRD-antibody complex to ALKAL2-AD detected by BLI. d, Neuroblastoma (IMR32) cells preincubated with the indicated concentrations of fab123 were stimulated with purified ALKAL2-AD. Phosphorylation of endogenous ALK at Y1604 (pALK) and total ALK were assessed by immunoblotting and quantified. Data represent mean ± SD of three independent measurements. For gel source data, see Supplementary Figure 1.