* indicates difference from baseline. ^ indicates difference between groups.
(A) All male groups except Isolated Saline differ from baseline following HFS. The Isolated KET 5mg/kg has a significantly greater increase from baseline than Isolated Saline (p<0.05). (Paired with saline treatment n=5, Isolated with saline treatment n=5, Isolated with 2.5 mg/kg KET treatment n=5, Isolated with 5.0 mg/kg KET treatment n=5)
(B) All proestrus female groups increased from baseline. The Isolated KET 5mg/kg treatment had a significantly greater increase from baseline than Isolated Saline (p<0.05) (Paired with saline treatment n=6, Isolated with saline treatment n=4, Isolated with 2.5 mg/kg KET treatment n=6, Isolated with 5.0 mg/kg KET treatment n=4)
All diestrus female groups increased from baseline but none differed from each other in responses. (Paired with saline treatment n=5, Isolated with saline treatment n=5, Isolated with 2.5 KET mg/kg treatment n=4, Isolated with 5.0 mg/kg KET treatment n=4).