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. 2021 Nov 24;53(11):1759–1768. doi: 10.1038/s12276-021-00707-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — The Sox2 O-GlcNAcylation level is high under ESC self-renewal conditions and decreases upon ESC differentiation. When Sox2 T258 O-GlcNAcylation is inhibited, the suppression of developmental genes by Sox2 does not occur properly, decreasing ESC self-renewal. In addition, Sox2 T258 O-GlcNAcylation is important for the development of ectoderm through the repression of mesendodermal genes. The reduction in Sox2 T258 O-GlcNAcylation during early embryonic development decreases the number of cells committed to an ectodermal lineage.