(A) Representative image of lumbar spine region of interest. (B,C) Percent change in BMD from baseline in Females (B) and Males (C) Percent decrease in Fracture group is greater in males. (D,E) Percent change from baseline in BMC for Females (D) and Males (E), with no significant differences between Fracture and Control Mice. (F) Representative image of uninjured femur diaphysis region of interest. (G,H) Percent change in BMD from baseline in Females (G) and Males (H) Percent decrease in Fracture group is greater in Males. (I,J) Percent change from baseline in BMC for Females (I) and Males (J), with no significant differences between Fracture and Control Mice.