(A,B) Differences in Quadriceps mass between Control (Uninjured), Contralateral, and Fracture limbs for Females (A) and Males (B). Both sexes show significant decreases in Fracture Quadriceps mass 2 weeks post-fracture, but no difference between Control and Contralateral limbs. Fracture limb mass remains significantly lower 6 weeks post-fracture in females and there is a trend in males. (C,D) Differences in Gastrocnemius mass between Control (Uninjured), Contralateral, and Fracture limbs for Females (C) and Males (D). Both sexes show significant decreases in Fracture Gastrocnemius mass 2 weeks post-fracture, but no difference between Control and Contralateral limbs, but no differences between muscle types at Week 6.