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. 2021 Nov 29;53(11):1781–1791. doi: 10.1038/s12276-021-00708-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Vitamin D₃ (5 × 10⁵ IU kg⁻¹) was administered for 3 days, and mice were euthanized on the ninth day. a Vitamin D₃ induced MDM2 expression (90 kDa band) in the mouse aorta. b Western blot analysis showing Mdm2, Runx2, and Hdac1 in aortas from Mdm2^fl/fl (wild-type) and SM22α-cre;Mdm2^fl/fl (VSMC-specific Mdm2 knockout) mice. c Aortas were stained with Alizarin red S. d Changes in the aortic calcium content. The data were shown as the mean ± s.e.m. values. P values for the different comparisons are shown in the figure (n = 4).