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. 2021 Nov 29;53(11):1781–1791. doi: 10.1038/s12276-021-00708-6

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© The Author(s) 2021

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Fig. 3 — a Truncated Mdm2 promoter constructs were used in the study. b Pi responsiveness of the truncated Mdm2 promoter activity. Note that Pi increased the activity of both the 1.5-kb and 2.9-kb promoters but not of the 1-kb or shorter promoters. c Promoter analysis showing the Pi responsiveness of the Mdm2 promoter with mutation of the MSX binding element (MSXE, −1331 to −1327 bp, shown as a red box in Fig. 3a). d Transfection of either Msx1 or Msx2 activated the wild-type MDM2 promoter but failed to activate the MSXE mutant MDM2 promoter. e Chromatin immunoprecipitation analysis. f Promoter analysis. Pi failed to activate the MDM2 promoter in an Msx1- or Msx2-dependent manner. A10 cells were used.