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. 2021 Dec 2;11:23314. doi: 10.1038/s41598-021-98792-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Top 25 transcription factor target gene sets significantly enriched in GSEA (P_adj < 0.05) ranked by NES (normalised enrichment score). Gene sets with a positive NES are enriched by genes with skeletal muscle baseline expression positively correlated to ΔS_i while genes with a negative NES are enriched by genes with skeletal muscle baseline expression negatively correlated to ΔS_i. Sets corresponding to MEF2A target genes are highlighted in red. A full list of significant transcription factor target gene sets is available on Supplementary Table S3.