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. 2021 Dec 2;12:7047. doi: 10.1038/s41467-021-27343-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Small angle X-ray scattering profiles of averaged, and background subtracted data from the apex of the inline size exclusion chromatography peak for EphA2 WT (residues S570-I976) and 5 mutants as indicated. b Guinier analysis of the data shown in a; the Guinier fit is indicated by a black line. c Pairwise distance distribution, P(r), plot, calculated from scattering data with GNOM. Maximum particle dimensions (D_max) are indicated for each mutant. d Ab initio SAXS envelopes for EphA2 WT and EphA2 5E calculated with DAMIFF. e Comparison between SAXS envelopes for EphA2 WT and 5E mutant with the crystal structures of EphA2 WT (molecules A and B) and the S897E/S901E mutant. Source data for a, b, c are provided in the Source Data file.