Table 3.
Prediction of antimicrobial resistance genes, functional classification, antibiotic types, and biosynthesis pathway of S. aureus DC.RB_015
| Types of resistance genes | Functional classification | Antibiotic types | Pathway ID |
|---|---|---|---|
| APH(3’)-IIIa (Aminoglycosides) |
Aminoglycoside 3′-O-phosphotransferase, which modifies the amino group by phosphorylation Glycosides |
Kanamycin, Barrotomycin, Isapamycin, Butirosine, Gentamicin, Penicillin, Ribomycin, Neomycin, Amikacin | – |
| ErmB (Macrolides) | rRNA adenine N-6-methyltransferase can methylate adenine at position 2058 of 23S rRNA, giving erythromycin resistance | Streptomycin B, Erythromycin, Lincosamide | – |
| aad(6) (Aminoglycosides) | Aminoglycoside 6′-adenosyltransferase | Aminoglycoside | – |
| SAT-4 (Nucleosides) | Streptomycin acetyltransferase A | Nucleoside | – |
| mecA (β-lactams) | Penicillin-binding proteins have low affinity for β-lactam and catalyzes penicillin-insensitive transpeptidase | β-lactam, Methicillin | Ko01501 |
| mepA (Glycylcyclines) | Multiple antibacterial extrusion (MATE) family proteins, multi-drug resistant efflux pump | Tigecycline | – |
| tet(K) (Tetracyclines) | Superfamily transporter, tetracycline efflux pump | Tetracycline | – |
| arlR (Fluoroquinolones) | Major Facilitator Superfamily (MFS) antibiotic efflux pump | Fluoroquinolone | – |
| arlS (Fluoroquinolones) | Major Facilitator Superfamily (MFS) antibiotic efflux pump | Fluoroquinolone | – |
| norA (Fluoroquinolones) | Major Facilitator Superfamily (MFS) antibiotic efflux pump | Fluoroquinolone | – |
| mgrA (Fluoroquinolones) | ATP binding cassette (ABC) antibiotic efflux pump; the main facilitator superfamily (MFS) antibiotic efflux pump | Fluoroquinolones, Cephalosporins, Penicillins, Tetracyclines, Peptides | – |
| tet(38) (Tetracyclines) | Major Facilitator Superfamily (MFS) antibiotic efflux pump | Tetracycline | – |
| LmrS (Macrolides) | Major Facilitator Superfamily (MFS) antibiotic efflux pump | Macrolide, Aminoglycoside, Oxazolone, Diaminopyrimidine, Fenicol | – |
| glpT (Fosfomycin) | Mutant glpT, resistant to fosfomycin | Fosfomycin | – |
| murA (Fosfomycin) | Mutant MurA, resistant to fosfomycin | Fosfomycin | – |
| BacA (Polypeptides) | Undecenyl pyrophosphate phosphatase leads to the separation of base pyrophosphate | Bacitracin | Ko00550 |
| blaZ (Penicillins) | Penicillinase extrudes the β-lactam antibiotic ring and invalidates the antibacterial properties of the molecule | Penicillin | Ko01501 |
| mecR1 (Penicillins) | Methicillin-resistance mecR1 proteins | Methicillin | – |
The antimicrobial resistance genes family, resistance mechanism, and predicted protein sequence are separately outlined in Table S5