Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Dec 2;11:23292. doi: 10.1038/s41598-021-01324-0

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Effect of Autoantibody profile in SS-associated epigenetic signals. (a) Hierarchical clustering representation from SS patients and healthy individuals (in columns) accordingly to DNA methylation levels (in rows) at the top SS-associated CpG sites. Subjects are classified according to disease status (green) and the presence of Anti-Ro/SSA (purple) and Anti-La/SSB (light blue) autoantibodies. (b) Barplot representing the effect sizes obtained in different models where DNA methylation was contrasting between different SS patients (according to autoantibody profiles). Black bar is a model that contrasted SSA- SS patients with CTRLs. Grey bar is a model that included all SS patients and was adjusted by SSA. Green bar is a model that included all SS patients and was unadjusted by SSA. Yellow line is a model that compared SSA + SS patients and CTRL. Blue line is a model that contrasted SSA + patients with CTRLs adjusted by SSB. Red bar is a model that contrasted SSA + SSB + patients and CTRLs. (c) Boxplots representing DNA methylation differences across different groups in three selected genes. R software⁷³ and Adobe Illustrator (https://www.adobe.com/) was used to create figures.