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. 2021 Dec 2;11:23292. doi: 10.1038/s41598-021-01324-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Functional Enrichment Results for differentially methylated regions based in Reactome database. (a) Dotplot representing Reactome functional pathways that are enriched in differentially methylated regions. Only significant pathways (adjusted P < 0.05) that are represented by more than 5 genes are illustrated. (b) Enrichment map that organizes significant enriched terms into a network with edges connecting overlapping gene sets. (c) Genes that are involved in significant terms are connected by linkages. Pathways in red are enriched in hypomethylated genes while pathways in blue are enriched in hypermethylated genes. Dot size represents number of genes with DMRs per pathways. R software⁷³ and Adobe Illustrator (https://www.adobe.com/) was used to create figures.