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. 2021 Dec 2;11:23292. doi: 10.1038/s41598-021-01324-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Intermediary role of DNA methylation and gene expression in SS genetic risk. (a) The minor G-allele of SNP rs1051047 exerts a protective role on SS susceptibility by increasing DNA methylation levels at the upstream region of gene IFI44 (cg1488022). (b) The minor C-allele of SNP rs9838739 exerts risk on SS susceptibility by decreasing DNA methylation levels at the intergenic region within the CCR cluster in chromosome 3 (cg03879629). (c) The minor T-allele of SNP rs2523425 exerts risk on SS by decreasing TRIM27 gene expression. (d) The minor G-allele of SNP rs76397273 exerts a protective effect on SS by decreasing GBP5 gene expression. Green boxplots and barplots represent SS population, while grey plots represent the healthy control population. DNA methylation is quantified with β-values, gene expression is at the logarithmic scale. R software⁷³ and Adobe Illustrator (https://www.adobe.com/) was used to create figures.