Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Dec 2;11:23292. doi: 10.1038/s41598-021-01324-0

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Disease interacting QTLs (a) The minor C-allele of SNP rs13273708 is associated with a decrease in DNA methylation levels at LY6E gene only in SS patients (ß_SS.meQTL = − 0.018, P_SS.meQTL = 6 × 10^–04), but not in the healthy population (P_SS.meQTL > 0.05). (b) The minor A-allele of SNP rs902834 decreases the DNA methylation level at STAT1 only in SS patients (ß_SS.meQTL = − 0.024, P_SS.meQTL = 0.0012), and not the healthy population (P_CTRL.meQTL > 0.05). (c) The minor T-allele of rs1079396 is associated with SGK269-methylation in SS patients (ß_SS.meQTL = -0.017, P_SS.meQTL = 0.0119), but not in the healthy population (P_CTRL.meQTL > 0.05). (d) The minor G-allele of rs7169481 in ATP10A is associated with increased DNA methylation at ATP10A in SS patients (ß_SS.meQTL = 0.018, P_SS.meQTL = 0.0047). However, in the healthy population this allele has no significant effect (P_CTRL.meQTL > 0.05). (e) The minor T-allele of the rs9305702 genetic variant is associated with a decreased MX2 gene expression in SS patients (ß_SS.eQTL = − 0.302, P_SS.eQTL = 1.8 × 10^–04), and shows no evidence of association in the healthy population (P_CTRL.eQTL > 0.05). (f) The minor C-allele of rs12364973 is associated with an increased IFITM1 gene expression in SS patients (ß_SS.eQTL = 0.28, P_SS.eQTL = 0.012) and shows no evidence of association in the healthy population (P_CTRL.eQTL > 0.05). (g) In SS patients, NUBI expression decreases with the dose of the minor A-allele of rs77466830 (ß_SS.eQTL = − 0.15, P_SS.eQTL = 3.5 × 10^–04); however, in the healthy population it remains stable (P_CTRL.eQTL > 0.05). (h) In SS patients, PLSCR1 expression increased with the dose of the minor A-allele of rs56077428 (ß_SS.eQTL = 0.357, P_SS.eQTL = 0.0208); however, in the healthy population it remains stable (P_CTRL.eQTL > 0.05). Green boxplots represent SS population, while grey boxplots represent the healthy control population. DNA methylation is quantified with β-values, gene expression is at the logarithmic scale. R software⁷³ and Adobe Illustrator (https://www.adobe.com/) was used to create figures.