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. 2021 Nov 19;11:748465. doi: 10.3389/fonc.2021.748465

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Copyright © 2021 Gao, Sun, Gu, Li, Xu, Xue, Li, Zhao, Zhou, Bai, Han and Zhao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CRC-exosomes induced differentiation of hAD-MSCs into CAFs. (A) Comparison of adipogenic (Oil red O staining, day11) and osteogenic (Alizarin red staining, day14) differentiation ability between hAD-MSCs and CAFs. (B) Detection of CRC-exosomes specific marker proteins by Western Blot. (C) Ultrastructure of exosomes (black arrows) purified from HCT116 under TEM. (D) Exosomes from HCT116 (Dil-labeled) ingested by hAD-MSCs were verified with fluorescence microscopy after incubating for 4 hours. Red: Exosomes (Dil). Blue: Nucleus (Hoechst 33342). (E) Western Blot analysis showed that the expression of CAFs-specific proteins was upregulated after induction with CRC-exosomes.