Table 2.
Total antioxidant capacity (TAC) after coronary artery reperfusion.
| References | Measure | Baseline | 10 min | 30 min | 1–12 h | 24–48 h | |
|---|---|---|---|---|---|---|---|
| Jalakandan et al. (31) | GSH (nmol/ml) | Ctr | 32.79 ± 15.78 | 24.25 ± 11.56 | |||
| NAC | 28.18 ± 10.14 | 33.82 ± 11.70 | |||||
| P | 0.225 | 0.005 | |||||
| Ozaydin et al. (37) | TACa (mmol Trolox/L) | Ctr | 1.6 (0.7–3.0) | 1.4 (0.6–3.2) | |||
| NAC | 1.6 (0.7–2.9) | 1.9 (0.9–3.9) | |||||
| P | 0.89 | <0.0001 | |||||
| Buyukhatipoglu et al. (39) | serum TAC (mmol Trolox/L) | Ctr | 0.84 ±0.14 | 0.77 ±0.09 | |||
| NAC | 0.88 ±0.12 | 0.81 ±0.07 | |||||
| P | NS | NS | |||||
| urine TAC (mmol Trolox/L) | Ctr | 1.52 ± 0.10 | 1.47 ± 0.16 | ||||
| NAC | 1.56 ± 0.12 | 1.49 ± 0.10 | |||||
| P | NS | NS | |||||
| Kurian et al. (40) | glutathione peroxidase (U/g Hb) | Ctr | 6.30 ± 1.2 | 6.33 ± 1.1 | 5.89 ± 0.9 | 5.26 ± 0.9 | |
| NAC | 6.41 ± 1.1 | 5.41 ± 1.0 | 4.36 ± 0.8 | 5.26 ± 0.9 | |||
| P | NS | NS | <0.05 | NS | |||
| glutathione reductase (U/g Hb) | Ctr | 1.08 ± 0.16 | 0.41 ± 0.07 | 0.42 ± 0.08 | 0.68 ± 0.08 | ||
| NAC | 1.106 ± 0.16 | 0.426 ± 0.07 | 0.496 ± 0.08 | 0.747 ± 0.08 | |||
| P | NS | NS | <0.05 | <0.05 | |||
| Superoxide dismutase (U/g Hb) | Ctr | 3829.1 ± 323 | 1218.6 ± 255 | 1258.9 ± 213 | 1375.9 ± 221 | ||
| NAC | 3938.8 ± 340 | 1264.7 ± 241 | 1334.1 ± 254 | 1461.8 ± 222 | |||
| P | NS | NS | <0.05 | <0.05 | |||
| Catalase (pM H202 /min /g Hb) | Ctr | 625.72 ± 20.5 | 985.27 ± 37.6 | 901.02 ± 36.1 | 869.93 ± 33.7 | ||
| NAC | 620.44 ± 21.73 | 955.87 ± 39.14 | 859.47± 35.22 | 741.38 ± 34.23 | |||
| P | NS | NS | <0.05 | <0.05 | |||
| Prabhu et al. (42) | GSH a (mg/g Hb) | Ctr | 0.7 ± 0.08 | 1.3 ± 0.20 | 1.25 ± 0.18 | 1.21 ± 0.15 | |
| NAC | 0.75 ± 0.03 | 1.6 ± 0.10 | 1.66 ± 0.05 | 1.31 ± 0.14 | |||
| P | NS | <0.001 | <0.01 | NS | |||
| Glutathione peroxidasea (U/g Hb) | Ctr | 42.6 ± 2.7 | 80.4 ± 6.4 | 59 ± 8 | 51.6 ± 5.6 | ||
| NAC | 40.6 ± 3.4 | 85.7 ± 3.7 | 62.7 ± 2.7 | 55 ± 1.4 | |||
| P | NS | <0.01 | NS | <0.05 | |||
| Glutathione reductasea (μg/min/g Hb) | Ctr | 8.6 ± 0.4 | 9.9 ± 0.48 | 10.1 ± 0.5 | 9.8 ± 0.4 | ||
| NAC | 8.6 ± 0.4 | 10.5 ± 0.5 | 10.4 ± 0.4 | 9.5 ± 0.1 | |||
| P | NS | <0.001 | <0.001 | NS | |||
| Superoxide dismutase a (U/g Hb) | Ctr | 367 ± 33 | 644 ± 31 | 564 ± 31.8 | 531 ± 31 | ||
| NAC | 377 ± 27 | 708 ± 15 | 582 ± 18 | 537 ± 32 | |||
| P | NS | <0.001 | NS | NS | |||
| Catalase a (μmol H2O2/ min/g Hb) | Ctr | 3.7 ± 1.30 | 6.0 ± 0.42 | 5.8 ± 0.60 | 5.7 ± 0.30 | ||
| NAC | 4.0 ± 1.0 | 6.4 ± 0.47 | 5.8 ± 0.10 | 5.4 ± 0.40 | |||
| P | NS | <0.01 | NS | NS | |||
| Köksal et al. (44) | Glutathione peroxidase a (U/g Hb) | Ctr | 24.3 ± 10.7 | 22.5 ± 8.9 | |||
| NAC | 27.7 ± 8.3 | 28.7 ± 12.9 | |||||
| P | NS | NS | |||||
| Yang et al. (56) | GSH (mol/L) | Ctr | 2.0 ± 2.4 | 1.4 ± 0.3 | 1.4 ± 0.4 | ||
| NAC | 2.2 ± 2.4 | 2.8 ± 1.3 | 2.8 ± 1.2 | ||||
| P | NS | <0.05 | <0.05 |
All numbers represent means ± SDs unless they are italicized, which indicate median (with interquartile ranges, IQR). Ctr: control group, NAC: N-acetylcysteine group. NS: non-significant.
“a″
indicates that the value was extracted from the figures of the cited publication. TAC: total antioxidant capacity, GSH: reduced glutathione, U/g: units per gram, Hb: Hemoglobin, mmol: millimole(s), nmol: nanomole(s).