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. 2021 Nov 19;12:758391. doi: 10.3389/fgene.2021.758391

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Copyright © 2021 Rajagopalan, Singh and Khiabanian.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Kaplan-Meier survival analysis of TCGA tumors based on their cilium expression. (A) Patients with TCGA tumors in the cilium bicluster had worse overall survival (OS) compared to other patients. (B) Patients with tumors in the top 25% cilium risk score had poorer OS compared to patients with tumors in the bottom 25% cilium risk score. (C) Patients with IDH1/2 wild-type gliomas with cilium risk scores below the population’s median had poorer OS compared to those with scores above the median. (D) Cilium risk score stratified patient OS in biclusters associated with poor prognosis, including a bicluster enriched in cell cycle. (E) Cilium risk score was reproducibly predictive of OS for patients in the independent REMBRANDT cohort.