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Overview of USP7 effects on cell apoptosis by interacting with its substrates. This model summarizes how USP7 effects p53-dependent cell apoptosis (A) and p53-independent cell apoptosis (B, C). Dotted arrow: deubiquitination; Brackets with a “+”: promotional effect; Brackets with a “-”: inhibitory effect. USP7, ubiquitin-specific peptidase 7; FOXO4, forkhead box O4; TRIM27, tripartite motif protein 27; TNF-α, tumor necrosis factor-alpha.
