Table 1.
Substrates or related proteins of USP7.
| Substrates or related proteins | Processes | References |
|---|---|---|
| NF-κB | Inflammatory signaling | (19) |
| HSCARG | NF-κB signaling | (20, 21) |
| IKK-γ
a
TRAF6 b |
Innate immunity | (22) |
| ICP0 | Innate immune response Viral infection |
(22, 23) |
| LANA c | Viral infection | (24) |
| vIRF d | (25, 26) | |
| RTA e | (27) | |
| E1B‐55 K | (28) | |
| UL35 | (29) | |
| EBNA1 f | (30) | |
| Foxp3 g | Tumor evasion | (31) |
| VP24 protein | Innate immune evasion | (32) |
| Tip60 | DNA damage responses Cell apoptosis Tumor evasion |
(21, 31, 33, 34) |
| P53 | DNA damage repair DNA damage responses Cell proliferation, migration, and apoptosis Tumor progression Tumor suppression |
(1, 8, 31, 35–40) |
| MDM2 | P53 degradation Cell proliferation Cell apoptosis |
(31) |
| HDM2, HDMX | P53 destabilization and downregulation | (8) |
| CCDC6 h | DNA damage responses DNA repair |
(1) |
| CHK1 i | Double-strand DNA breaks Cell cycle Tumor resistance |
(1, 8, 41–43) |
| XPC j | Nucleotide excision repair (NER) | (10) |
| CSB k /ERCC6 | Transcription‐coupled nucleotide excision repair (TC‐NER) | (1, 44, 45) |
| HLTF l | DNA damage bypass Damaged gene replication Cell cycle |
(1, 46) |
| CHFR m | Cell cycle | (47) |
| Cyclin A2 | (48) | |
| Ki-67 antigen | (49) | |
| UHRF1 n | Replication | (1, 50) |
| Histone LSD1 | Cell proliferation and migration | (4) |
| MDC1° | Double-strand DNA breaks Homologous recombination |
(51) |
| PHF8 p | DNA damage responses Cell cycle |
(1, 4, 48, 52) |
| ANXA1 q | DNA damage responses Cell apoptosis |
(53) |
| Rad18 | DNA damage tolerance Cell cycle |
(46) |
| RNF168
r
RNF169 s |
DNA damage responses | (4, 8, 11, 12) |
| DNA polymerase polη | DNA damage | (54, 55) |
| RNA polymerase II | CSB stabilization Nucleotide excision repair (NER) |
(1) |
| UVSSA t | CSB stabilization Transcription‐coupled nucleotide excision repair (TC‐NER) |
(1, 44, 45) |
| DNMT1 u | Replication Cell proliferation and migration |
(1, 4, 56) |
| PTEN | Tumor metastasis Cell apoptosis Tumor suppression |
(1, 57, 58) |
| Claspin | Tumor suppression | (43) |
| FOXO v | (16) |
a
IκB kinase γ.
b
Tumor necrosis factor (TNF) receptor associated factor 6.
c
Latency‐associated nuclear antigen.
d
Viral interferon regulatory factor.
e
RNA transcriptional activator.
f
Epstein‐Barr nuclear antigen 1.
g
Forkhead box P3.
h
Coiled-coil domain containing 6.
i
Checkpoint kinase 1.
j
Xeroderma pigmentosum complementation group C.
k
Cockayne syndrome B.
l
Helicase-like transcription factor.
m
Checkpoint protein with FHA and RING domains.
n
Ubiquitin‐like, containing PHD and RING finger domains 1.
° Mediator of DNA damage checkpoint 1.
p
Plant homeodomain finger‐containing protein 8.
q
Annexin‐1.
r
Ring finger protein 168.
s
Ring finger protein 169.
t
UV-stimulated scaffold protein A.
u
DNA methyltransferases 1.
v
Forkhead box O.