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. 2021 Nov 19;9:758402. doi: 10.3389/fcell.2021.758402

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Copyright © 2021 De Rosa, Johnson and Opresko.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The impact of 8-oxoguanine on a G-quartet. G-quadruplexes consist of two or more stacked G-quartets and central monovalent cations. These planar arrangements of four guanine bases are stabilized by hydrogen bonding on their Hoogsteen face (highlighted by green dashed line on one representative base). Conversion of the guanine to 8-oxoguanine (affected atoms and bonds in orange) introduces a steric clash with the adjacent guanine that prevents them from forming a Hoogsteen binding interaction, destabilizing the G-quartet and the G-quadruplex as a whole.