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. 2021 Jun 25;45(6):840–852. doi: 10.4093/dmj.2020.0291

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Copyright © 2021 Korean Diabetes Association

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 3. — Endocrine actions of brown adipose tissue (BAT)-derived factors. Brown/beige adipocytes secrete various molecules, some of which such as nerve growth factor (NGF) and vascular endothelial growth factor (VEGF) function as paracrine factors, while others as endocrine factors, acting on the liver and skeletal muscle, thereby regulating systemic metabolism. 12,13-diHOME, 12,13-dihydroxyoctadecaenoic acid; FA, fatty acid; FGF21, fibroblast growth factor 21; IL-6, interleukin-6; miR, microRNA; NRG4, neuregulin 4.