Fig. 7.

A multi-state cartoon model accounting for the catalytic process mediated by SaPgsA.

The grey shading indicates the estimated membrane region. The red and blue elliptical rings indicate the vertical and lateral portals for the entry of G3P and CDP-DAG (or for the release of CMP and PGP) respectively. Among the five putative states (I-V), State II represents the one observed in the SaPgsA−CDP-DAG complex structure, whereas State V corresponds to the state of the SaPgsA−PGP complex structure. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)