Table 3.
Univariate and multivariate analyses of risk factors for MVI.
| Variables | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| OR | 95%CI | P-value | OR | 95% CI | P-value | |
| Age (≥50 vs <50) | 1.067 | 0.096-11.837 | 0.958 | |||
| Sex (male vs female) | 0.571 | 0.118-2.762 | 0.486 | |||
| HBV infection | 6.761 | 0.841-54.374 | 0.072 | |||
| Alb (>40 vs ≤ 40) | 1.712 | 0.387-7.572 | 0.479 | |||
| TBIL (>50 vs ≤ 50) | 2.087 | 0.329-13.235 | 0.435 | |||
| DBIL (>6.8 vs ≤ 6.8) | 5.270 | 0.251-110.61 | 0.285 | |||
| ALT (>50 vs ≤ 50) | 13.122 | 0.658-261.57 | 0.092 | |||
| AST (>40 vs ≤ 40) | 0.219 | 0.017-2.756 | 0.240 | |||
| ALP (>125 vs ≤ 125) | 1.619 | 0.174-15.069 | 0.672 | |||
| GGT (>50 vs ≤ 50) | 1.214 | 0.206-7.149 | 0.830 | |||
| PT (>13 vs ≤ 13) | 0.902 | 0.077-10.608 | 0.195 | |||
| INR (per 0.1 increase) | 0.208 | 0.012-3.619 | 0.281 | |||
| (>1.0 vs ≤ 1.0) | ||||||
| PLT | 1.006 | 0.995-1.017 | 0.256 | |||
| CEA (>5 vs ≤ 5) | 0.779 | 0.129-4.688 | 0.785 | |||
| CA-199 (>37 vs ≤ 37) | 1.469 | 0.371-5.820 | 0.584 | |||
| Tumor size | 0.990 | 0.953-1.029 | 0.617 | |||
| Cirrhosis | 0.967 | 0.086-10.835 | 0.978 | |||
| No. of segments involved (single vs two/more) | 2.244 | 0.508-9.519 | 0.287 | |||
| Satellite nodules | 33.154 | 2.689-408.79 | 0.006 | 13.726 | 3.144-59.93 | <0.001 |
| lymph node metastasis | 4.386 | 0.906-21.247 | 0.066 | |||
| Intrahepatic duct dilatation | 0.252 | 0.034-1.882 | 0.179 | |||
| Tumor contour (well-defined vs blurry/infiltrative) | 7.535 | 1.267-42.660 | 0.026 | 4.992 | 1.757-14.18 | 0.003 |
| Arterial rim- enhancement | 2.135 | 0.315-14.443 | 0.437 | |||
| Arterial hypo-enhancement | 20.298 | 2.365-174.22 | 0.006 | 4.308 | 1.554-11.94 | 0.005 |
| Intratumor vascularity | 0.814 | 0.213-3.120 | 0.764 | |||
| Hepatic capsular retraction | 1.400 | 0.256-7.662 | 0.698 | |||
MVI, microvascular invasion; HBV, hepatitis B virus; Alb, albumin; TBIL, total bilirubin; DBIL, direct bilirubin; ALT, alanine aminotransferase; AST, aspartate transaminase; ALP, alkaline phosphatase; OR, odds ratios; GGT, γ-glutamyl transpeptidase; CI, confidence intervals; PT, prothrombin time; INR, international normalized ratio; PLT, platelets; CEA, carcinoembryonic antigen; CA-199, cancer antigen 19-9.