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. 2021 Nov 19;12:770223. doi: 10.3389/fphys.2021.770223

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Copyright © 2021 Liu, Sun, Li, Xu, Xiao, Wang, Song, Bai, Wen, Ge, Zhang, Song and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Defining of a potential metabolic biomarker for CAE. (A) Score plot of the first (PC1) and second (PC2) PCs (horizontal and vertical axes, respectively) from principal component analysis of arachidonic acid metabolites in discovery sets. (B) VIP value of metabolites from PCA analysis in discovery sets. (C) Venn diagram shows an overlap between metabolites with VIP value > 1 and P-value < 0.05. (D) Fold change of eight serum metabolites from C in discovery sets. CAE, coronary artery ectasia; PCA, principal component analysis.