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. 2021 Nov 19;9:765085. doi: 10.3389/fcell.2021.765085

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Copyright © 2021 Cavini, Leonardo, Rosa, Castro, D’Muniz Pereira, Valadares, Araujo and Garratt.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Model for how antiparallel coiled coils could mediate septin filament interconnections (Leonardo et al., 2021). The G- and the C-domains are represented as spheres and rods, respectively. (A) Loosely-paired filaments (or a “railroad-track”) separated by 15–20 nm are likely to be connected by antiparallel homodimers formed by the coiled coils of SEPT6 and SEPT7. (B) Tightly-paired sheets of filaments interconnected by antiparallel homodimers of SEPT2 coiled coils. (C) Solvent-protection of the hydrophilic side of the interface (a positions, green) in the antiparallel coiled coils. By facing the membrane, where the dielectric constant is lower than in bulk solvent, the formation of polar interactions is favored (black dashes).