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. 2021 Nov 19;9:711965. doi: 10.3389/fcell.2021.711965

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Copyright © 2021 Xue, Gu, Li, Bao and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Correlation of eIF4A family gene expression with immune infiltration level and tumor purity. We adopted the TIMER website to detect the association of eIF4A family gene expression and immune infiltration levels. The mRNA expression levels of eIF4A family genes (eIF4A1, eIF4A2, and eIF4A3) were significantly correlated with the infiltration levels of various immune cells. The color of the bubble of the graph indicates the difference in each of the various types of cancers, and the bubble size indicates the statistical significance of the correlation. A correlation >0 indicates a positive association of eIF4A family genes and immune cells in various cancers. A two-tailed p < 0.05 was considered significant. Abbreviations: Kidney Renal Clear Cell Carcinoma (KIRC); Kidney Renal Papillary Cell Carcinoma (KIRP); Kidney Chromophobe (KICH); Brain Lower Grade Glioma (LGG); Glioblastoma Multiforme (GBM); Breast Invasive Carcinoma (BRCA); Lung Squamous Cell Carcinoma (LUSC); Lung Adenocarcinoma (LUAD); Rectum Adenocarcinoma (READ); Colon Adenocarcinoma (COAD); Uterine Carcinosarcoma (UCS); Uterine Corpus Endometrial Carcinoma (UCEC); Ovarian Serous Cystadenocarcinoma (OV); Head and Neck Squamous Carcinoma (HNSC); Thyroid Carcinoma (THCA); Prostate Adenocarcinoma (PRAD); Stomach Adenocarcinoma (STAD); Skin Cutaneous Melanoma (SKCM); Bladder Urothelial Carcinoma (BLCA); Liver Hepatocellular Carcinoma (LIHC); Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (CESC); Adrenocortical Carcinoma (ACC); Pheochromocytoma and Paraganglioma (PCPG); Sarcoma (SARC); Acute Myeloid Leukemia (LAML); Pancreatic Adenocarcinoma (PAAD); Esophageal Carcinoma (ESCA); Testicular Germ Cell Tumors (TGCT); Thymoma (THYM); Mesothelioma (MESO); Uveal Melanoma (UVM); Lymphoid Neoplasm Diffuse Large B-cell Lymphoma (DLBC); Cholangiocarcinoma (CHOL).