TABLE 1.
Expression patterns and clinical significance of the eIF4A family in human malignancies.
| Isoform | References | Cancer type | Expression in tumor | Clinical significance | Prognosis |
|---|---|---|---|---|---|
| eIF4A1 | 22415234 | Endometrial cancer | High | Not studied | Not studied |
| 32147684 | Gastric cancer | High | Poor tumor differentiation, late T stage, lymph node metastasis, advanced TNM stage | Poor prognosis | |
| 25611378 | Breast cancer | Not studied | High histological grade | Poor prognosis | |
| 31807078 | Oral squamous cell carcinoma | Not studied | Poor differentiation | Poor prognosis | |
| 24844222 | Cervical cancer | High | Advanced stage, squamous cell histology, lymph node metastasis, deep stromal invasion | Poor prognosis | |
| 12970751 | Non-small cell lung cancer | Not studied | Metastasis | Poor prognosis | |
| eIF4A2 | 23867391 | Non-small-cell lung cancer | Low | Low histopathological classification, early tumor grade | Favorable prognosis |
| 31088567 | Colorectal cancer | High | distant metastasis, TNM stage IV | Poor prognosis | |
| 31308851 | Triple-negative breast cancer | High | Not studied | Not studied | |
| 32934744 | Esophageal squamous cell carcinoma | High | Not studied | Not studied | |
| eIF4A3 | 29571014 | Ovarian cancer | High | Not studied | Not studied |
| 31975383 | Hepatocellular carcinoma | High | Not studied | Not studied | |
| 32307743 | Gastric cancer | Low | Not studied | Not studied |