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. 2021 Nov 19;12:769321. doi: 10.3389/fphys.2021.769321

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Copyright © 2021 Sporkova, Ghosh, Al-Hasani and Hecker.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Localization and putative mechanisms of action of zyxin in EC and LPP in vascular SMC. Note that the putative mechanism of action of LPP is derived from our findings on the mechanism of action of zyxin in vascular SMC. Both LIM domain proteins seem to serve the same function in vascular SMC, that is, to maintain their quiescent contractile phenotype. Note that there is no LPP expression in adult EC of mouse or human origin. αVβ3 and α5β1, corresponding integrins; LASP1, LIM and SH3 domain protein 1; MRTF-A, myocardin-related transcription factor A; PDLIM1, PDZ and LIM domain protein 1; PDLIM5, PDZ and LIM domain protein 5; SRF, serum response factor.