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. 2021 Nov 19;12:775353. doi: 10.3389/fimmu.2021.775353

Figure 1.

Figure 1

Weighted gene correlation network analysis identifies an immunoglobulin signature associated with DLE skin lesion status, independent of IFN score. (A) Module-trait relationship heatmap. Each module eigengene was correlated with the indicated clinical parameter. For categorical parameters, non-systemic/systemic disease and DLE/SCLE, numerical values were assigned to each categorical group. The scale bar on the right represents the correlation coefficient with green for negative correlation and red for positive correlation, p-values for each correlation are presented on the heatmap. The yellow module was the module with the strongest positive correlation with IFN score and the cyan module was the module that had the strongest negative correlation with the DLE versus SCLE lesion status. (B) The cyan module eigengene from the SCLE and DLE lesions encompasses a 32-gene, primarily immunoglobulin signature. (C) The yellow module eigengene was significantly correlated with IFN score (r = 0.85, p = 3E-28). The data in each panel represent 47 DLE patients and 43 SCLE patients.