Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Nov 27;12:100171. doi: 10.1016/j.mtbio.2021.100171

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021 The Authors. Published by Elsevier Ltd.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Fig. 6 — EVs/RGD-biotin hydrogels enhanced the retention and stability of HIF-1α-EVs. (A) Chemical structure of the RGD-biotin molecule. (B) SEM image of RGD-biotin hydrogel revealed the formation of entangled nanofibers formed by the RGD-biotin molecule. (C) Biotin-GFFYGRGD was dissolved in PBS. After that, the suspension was heated to about 95 °C in order to dissolve the compound completely, and hydrogels formed after cooling back to room temperature. (D) EVs were incorporated in Biotin-GFFYGRGD and then injected into infarcted rat hearts. (E) The fate of EVs in vivo was tracked by bioluminescence imaging. Representative images are from rats receiving EVs incorporated in RGD hydrogels (EV/RGD-biotin) and naked EVs. (F) Quantification of bioluminescence imaging after injection. Continuous variables were described by means ± SEM. n=3 for each group.