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. 2021 Nov 27;12:100171. doi: 10.1016/j.mtbio.2021.100171

Fig. 9.

Fig. 9

Schematic of the working hypothesis. EVs released by MSCs with stabilized overexpression of HIF-1α contribute to angiogenesis and anti-apoptosis in part via enhanced expression of miR-221–3p. RGD hydrogels increased the therapeutic efficacy of HIF-1α engineered MSCs-derived EVs at a functional, histopathological and molecular level.