Table 1.

GPR56 in physiology.

Section	Physiological function	The role of GPR56/ADGRG1	References
1.1	Cerebral Cortex Development and Patterning	Proper cerebral cortex development and designing by inhibiting the migration of neurons hence preventing neuronal over migration and breaching of pial basement membrane	[17,23,28]
1.2	Rostral Cerebellum Development	Adhesion of rostral granule cells to extracellular matrix proteins such as laminin and fibronectin	[45]
1.3	CNS Myelination: Oligodendrocyte Progenitor Cell (OPC) Proliferation and Oligodendrocyte (OL) Development	Regulation of myelination by positively regulating OPC proliferation and negatively regulating pro-OL differentiation to OL	[31,47,96]
1.4	PNS Myelination by Schwann Cells (SCs)	Proper radial axonal sorting in SCs by cytoskeletal remodeling	[29]
1.5	Neural Stem and Progenitor Cells Maintenance	Maintenance of stemness or inhibition of differentiation	[69]
1.6	Synaptic Remodeling in CNS	Microglia-mediated synaptic pruning via detection of phosphatidylserine on apoptotic synapses	[24]
1.7	Stress and Depression	Anti-depressant-like activities	[70,97]
2.1	Hematopoietic Stem and Progenitor Cells	Endothelial-to-Hematopoietic Transition (EHT)	[57,59]
2.2	Hemostatic Shear Force Sensor	Platelet collagen-responsder and shear force sensor during hemostasis	[55]
2.3	Cytotoxic Lymphocytes Steady State	Inhibition of cytotoxicity and migration of cytotoxic lymphocytes during steady or inactivated state	[19]
3	Muscle Hypertrophy	Overload-induced or Apigenin-induced muscle hypertrophy	[48,49]
4	Pancreas/islet β-cell	Protection of β-cells from cytokine-induced apoptosis; increasing calcium-ion levels; glucose-induced insulin secretion	[60]
5	Adipose Tissue	Adipogenesis	[63]
6	Reproduction System Development	Asymmetric testis development and male fertility in mammals	[64]