Table 1.
List of clinical Candida glabrata isolates used in this study.
| Isolate # | Original # | Sequence type | Minimum inhibitory concentration (μg/ml) |
Susceptibility profiles | Comments | |||
|---|---|---|---|---|---|---|---|---|
| Fluconazole | Micafungin | Anidulafungin | AMB | |||||
| 1 | CAS08-0293 | ST3 | 64 | 4 | 4 | 1 | MDR | |
| 2 | CAS08-0725 (CMD00311) | ST3 | 64 | 0.5 | 2 | 1 | MDR | |
| 3 | CAS09-0869 (CMD00373) | ST3 | 64 | 0.5 | 2 | 1 | MDR | |
| 4 | BG2 | ST3 | 4 | 0.015 | 0.125 | 1 | S | |
| 5 | Qatar 36 | ST3 | 4 | 0.015 | 0.125 | 0.5 | S | |
| 6 | DPK 159 | ST3 | 4 | 0.015 | 0.125 | 1 | S | |
| 7 | DPL27 (5962) | ST3 | 4 | 2 | 4 or 2 | 1 | ECR | |
| 8 | ATCC 66032 | ST6 | 4 | 0.015 | 0.06 | 0.5 | S | |
| 9 | CAS09-1225 (CGA00908) | ST6 | > 64 | 4 | 2 | 2 | MDR | |
| 10 | CAS09-1786 (CGA01258) | ST6 | 64 | 4 | 2 | 1 | MDR | |
| 11 | DPL155 (M234) | ST6 | 1 | 0.25 | 1 | 1 | ECR | |
| 12 | DPL157 (17351, CGC2) | ST6 | 64 | 4 | 4 | 1 | MDR | |
| 16 | CAS08-0089 | ST8 | 4 | 0.015 | 0.125 | 1 | S | |
| 17 | CAS08-494 | ST8 | 4 | 0.015 | 0.125 | 1 | S | |
| 18 | CAS08-528 | ST8 | 4 | 0.015 | 0.125 | 1 | S | |
| 19 | CAS11-3112 (CGA02083) | ST8 | 64 | 0.25 | 0.5 | 1 | MDR | |
| 20 | DPL209 (M2952) | STX | 64 | 4 | 4 | 1 | MDR | |
| 25 | CAS08-0205 | ST10 | 4 | 0.015 | 0.125 | 0.5 | S | |
| 26 | CAS09-1083 (CGA00822) | ST10 | 64 | 0.5 | 1 | 0.5 | MDR | |
| 27 | CAS09-1437 (CGA01045) | ST10 | 64 | 2 | 1 or 0.5 | 1 | MDR | |
| 28 | DPK 305 | ST10 | 4 | 0.015 | 0.125 | 1 | S | WGS |
| 29 | CAS08-0425 (CMD00008) | ST10 | 64 | 4 | 4 | 1 | MDR | WGS |
| 35 | DPL1021 (ATCC 90030) | ST10 | 4 | 0.015 | 0.125 | 1 | S | WGS |
| 21 | Qatar 38 | ST15 | 4 | 0.015 | 0.25 | 1 | S | |
| 22 | Qatar 57 | ST15 | 4 | 0.015 | 0.125 | 1 | S | |
| 23 | Qatar 71 | ST15 | > 64 | 0.06 | 0.25 | 1 | FLZR | |
| 24 | ATCC 2001 (CBS 138) | ST15 | 4 | 0.015 | 0.125 | 0.5 | S | |
| 30 | CAS08-0027 | ST15 | 64 | 0.015 | 0.125 | 1 | FLZR | WGS |
| 31 | CAS08-485 | ST15 | 4 | 0.015 | 0.125 | 1 | S | |
| 32 | CAS09-755 | ST15 | 4 | 0.015 | 0.125 | 1 | S | |
| 33 | DPK 762 | ST15 | 4 | 0.015 | 0.125 | 1 | S | WGS |
| 34 | DPL274 (3-CPH-W20800) | ST15 | 1 | 1 | 4 | 4 | ECR | |
| 36 | CAS08-0092 | STY | 2 | 0.015 | 0.125 | 1 | S | |
| 37 | CAS11-3129 (CMD01408 | STY | 64 | 4 | 4 | 0.5 | MDR | |
| 38 | DPL245 (1611) | STY | 16 | 4 | 4 | 0.5 | ECR | WGS |
| 39 | DPL38 (42997) | STY | 32 | 1 | 2 | 0.25 | ECR | |
| 40 | CAS08-0016 (CGA00019) | STY | 64 | 2 | 1 | 1 | MDR | WGS |
| 41 | DPL217 | ST17 | 2 | 0.5 | 1 | 0.5 | ECR | |
| 42 | DPL219 | ST17 | 2 | 0.5 | 1 | 0.5 | ECR | |
| 44 | LB599-02 | ST46 | 4 | 0.015 | 0.125 | 1 | S | |
| 45 | LB906-05 | ST46 | 64 | 0.015 | 0.125 | 1 | FLZR | |
| 46 | Qatar 51 | ST46 | 2 | 0.015 | 0.125 | 1 | S | |
| 48 | Qatar 59 | ST46 | 2 | 0.015 | 0.06 | 1 | S | |
| 50 | Qatar 62 | ST46 | 2 | 0.015 | 0.06 | 1 | S | |
| 53 | Qatar 69 | ST46 | 4 | 0.03 | 0.25 | 1 | S | |
| 54 | Qatar 72 | ST46 | 64 | 0.015 | 0.125 | 1 | FLZR | |
| 56 | Qatar 76 | ST46 | 4 | 0.015 | 0.125 | 1 | S | |
| 47 | Qatar 53 | ST7 | 2 | 0.015 | 0.06 | 1 | S | |
| 49 | Qatar 61 | ST7 | 4 | 0.015 | 0.06 | 1 | S | |
| 51 | Qatar 63 | ST7 | 4 | 0.015 | 0.06 | 1 | S | |
| 52 | Qatar 64 | ST7 | 2 | 0.015 | 0.06 | 1 | S | |
| 55 | Qatar 73 | ST7 | 4 | 0.015 | 0.125 | 1 | S | |
| 57 | CAS08-0094 | ST76 | > 64 | 2 | 4 | 1 | MDR | |
AMB: Amphotericin B, MDR: Multidrug-resistant, S: Susceptible, ECR: Echinocandin-resistant, FLZR: Fluconazole-resistant, WGS: Whole-genome sequenced.