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Effect of exogenous AKG on collagen content and liver Tissue Factor activity in MTX induced hepatotoxicity (n = 6; mean ± SD; p < 0.01). $p < 0.01 when MTX group compared with control; ∗∗∗p < 0.01 when AKG supplemented group compared with MTX (One way ANOVA followed by Tukey's test).