Figure 2.

Boxplots and dot plots of the extent of the pathologic index for mesangial matrix expansion, glomerulosclerosis, tubulointerstitial damage, and artery/arteriole damage according to urinary albumin-to-creatinine ratio levels. (a) Mesangial expansion index; (b) global glomerulosclerosis; (c) interstitial fibrosis and tubular atrophy; (d) interstitial inflammation; (e) arterial intima-media ratio; and (f) arteriole hyalinosis index. The bold horizontal line represents the median, the box represents the 25th to 75th percentiles, the vertical bar represents the minimum to the maximum except for outliers, and the dots represent individual cases. Trends in the difference across albuminuria levels were tested by using a Jonckheere-Terpstra test. IFTA, interstitial fibrosis and tubular atrophy.