Table 1.

Structural parameters of the DG cell band: mean and SD (All, AD, CTRL)

Parameter (median over subject	All		AD		CTRL		p ${}^{*}$
Neuron population)	Mean	SD	Mean	SD	Mean	SD
Electron density ρ (1/nm3)	320.06	2.00	320.91	2.10	318.77	0.92	0.020
Heterogeneity s ($·{10}^{-5}$)	1.30	0.50	1.45	0.50	1.07	0.45	0.165
Volume v ($\mathrm{\mu }$m3)	115.46	34.26	101.85	28.31	135.88	34.21	0.073
Sphericity $\phi$	0.950	0.016	0.963	0.015	0.954	0.017	0.278
nn within radius of 13.5 $\mathrm{\mu }$m	4.93	1.39	5.44	1.42	4.17	0.983	0.061
Cell density ${\overline{\rho }}_n$ ($·{10}^5$ 1/mm3)	2.32	0.37	2.35	0.46	2.32	0.15	0.842
DG bandwidth $d_{\text{DG}}$ ($\mathrm{\mu }$m)	32.82	8.44	34.27	9.04	30.54	7.47	0.358
Next-neighbor distance $d_{\text{NN}}$ ($\mathrm{\mu }$m)	14.29	1.01	13.88	0.95	15.04	0.65	0.009
nn within radius of 13.5 $\mathrm{\mu }$m	4.83	1.47	5.18	1.66	4.29	0.95	0.166

The upper part refers to CB data and the lower part to PB data. For each subject, the median of the neuron population was calculated. p values reflect group differences only with respect to the parameter median, not the entire neuron population, which is probed by OT. $d_{\text{NN}}$ is derived from the structure factor maximum. The evaluation of the parameters is detailed in SI Appendix, Methods, Structural parameters of DG-cell nuclei. NN, number of neighbors.

${}^{*}$t test (Welch).