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Conformational changes in hSUR when coupled to an open pore. (A) Changes in the SUR lasso motif. Inhibitory ATP is colored red; KATP with a closed pore, gray. In KATP with an open pore, Kir is colored blue; SUR yellow. Backbone Cα atoms for Q52 (Kir) and E203 (SUR) are shown as spheres. (B) Cryo-EM density for SUR at five different positions (shown in different colors) relative to Kir. The location of SUR in the quatrefoil configuration (33) is shown in magenta.
