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Effect of ONC206 and ONC201 on cell proliferation in EC cells. The ECC-1 and Ishikawa cell lines were cultured in the presence of varying concentrations of ONC206 and ONC201 for 72 hours. Cell proliferation was determined by MTT assay. Based on the IC50 dose comparison, ONC206 demonstrated 14-20 times greater potency when compared to ONC201 (A). Western blotting results indicated that ONC206 induced the expression of DRD2 and DR5 in EC cells after 24 hours of treatment (B).
