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ONC206 induces cellular stress in EC cell lines. The ECC-1 and Ishikawa cell lines were treated with ONC206 at the indicated doses for 4 hours. ROS was assessed by DCFDA assay. ONC206 induced cellular ROS production in a dose-dependent manner in both cell lines (A). Western blotting results showed that ONC206 increased expression of the cellular stress proteins Ero1, Perk and Bip in both EC cell lines after 24 hours of treatment (B). (*P<0.05, **P<0.01).
