Figure 4.

ONC206 significantly decreased tumor weight in the Lkb1^fl/flp53^fl/fl EC mouse model. Lkb1^fl/flp53^fl/fl mice were fed a HFD (obese) or LFD (lean) starting at 3 weeks of age. Diet-induced obesity significantly increased the body weights of Lkb1^fl/flp53^fl/fl mice (A). The mice were treated with ONC206 (125 mg/kg, oral gavage, weekly) or vehicle for 4 weeks, beginning 8 weeks after tumor induction. ONC206 significantly inhibited tumor weight under obese and lean conditions (B). IHC results showed that ONC206 treatment reduced the expression of Ki67 and increased the expression of DRD2 and ClpP in endometrial tumor tissues (C). (*P<0.05, **P<0.01).