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. 2021 Nov 15;11(11):5374–5387.

Figure 5.

Figure 5

ONC206 induced apoptosis in vitro and in vivo. Cells were treated with ONC206 at the indicated doses for 24 hours and then analyzed for expression of Annexin V by Cellometer. ONC206 increased the expression of Annexin V in a dose-dependent manner in both cell lines (A). Western blotting results showed that ONC206 significantly reduced the expression of MCL-1 and BCL-XL in both cell lines (B). IHC results demonstrated that ONC206 decreased the expression of BCL-XL in endometrial tumor tissues (C). (*P<0.05, **P<0.01).