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ONC206 inhibited mTOR/S6 pathway in vitro and in vivo. The ECC-1 and Ishikawa cell lines were treated with ONC206 at varying doses for 24 hours. Western blotting results demonstrate that ONC206 decreased phosphorylation of S6 and increased phosphorylation of AKT in both cell lines (A). Treatment with ONC206 for 4 weeks significantly decreased the expression of phosphorylated S6 in endometrial tumor tissues of Lkb1fl/flp53fl/fl mice (B).
