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(A) Induction and repair of DSBs in V79 wild-type (WT) cell line and XRCC mutants XRCC2 (irs1), XRCC3 (irs1SF), CHO-K1 parent cell line, and XRCC5 (xrs5). Exponentially growing cells were treated with 16 μM HN2 for 1 h and subsequently allowed to repair in fresh medium for 4, 8, or 24 h. Control cells (C) were treated with drug-free medium. Samples were then analyzed by PFGE. (B) Semiquantitative analysis of the percentage of DNA released from plugs in the gel shown in panel A.
