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(A) Induction and repair of DSBs in AA8 wild-type (WT) cell line and NER mutants XPF (UV47), XPG (UV135), XPB (UV23), and ERCC1 (UV96). Exponentially growing cells were treated with 16 μM HN2 for 1 h and subsequently allowed to repair in fresh medium for 4, 8, or 24 h. Control cells (C) were treated with drug-free medium. Samples were then analyzed by PFGE. (B) Semiquantitative analysis of the percentage of DNA released from plugs from the gel shown in panel A.
