Figure 8.

CD7 blockade and CD7-CAR-T cells exhibit antitumor activity in an AML (HEL) CDX model. A. Schematic of the experiment. Luc⁺-GFP⁺-HEL cells were infused i.v. in 15 B-NDG mice at 5×10⁵ cells/mouse. Cohorts were randomized, and mice received 1×10⁷ CD7-blockade and CAR-T cells, with mice treated with PBS used for the controls. B. The survival of mice are analyzed by Mantel-Cox log-rank test and shown with Kaplan-Meier curves and. **P<0.01. C. AML cell growth evaluated using the IVIS system after CD7-CAR-T-cell infusion. D. Statistic analysis of the burden of Luc⁺ tumor cells in different groups. E. Body weight was monitored throughout the experiment. NS, not significant.